| 白细胞介素28B基因多态性与丙型肝炎患者干扰素疗效的关系 |
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| 引用本文： | 刘波,唐小平. 白细胞介素28B基因多态性与丙型肝炎患者干扰素疗效的关系[J]. 国际流行病学传染病学杂志, 2012, 39(4): 272-276 |
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| 作者姓名： | 刘波 唐小平 |
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| 作者单位： | 广州市传染病研究所, 广州医学院附属市八人民医院,510060 |
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| 摘 要： | 影响慢性丙型肝炎患者IFN抗病毒疗效的因素有宿主因素、病毒因素以及其他作用于病毒和宿主的外在因素，如吸烟、环境污染、合并其他病毒感染等。而最近的研究表明宿主IL-28B基因多态性与IFN抗HCV疗效的关系尤为重要。此文对IL-28B基因多态性对IFN抗HCV疗效影响进行综述。
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| 关 键 词： | 多态性 单核苷酸 白细胞介素28B 丙型肝炎 干扰素 |
Association of interleukin-28B polymorphisms with the response to interferon treatment of chronic hepatitis C |
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| LIU Bo , TANG Xiao-ping. Association of interleukin-28B polymorphisms with the response to interferon treatment of chronic hepatitis C[J]. International Journal of Epidemiology and Infectious Disease, 2012, 39(4): 272-276 |
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| Authors: | LIU Bo TANG Xiao-ping |
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| Affiliation: | (Institute of Infectious Diseases, Guangzhou No. 8 People＇s Hospital, Guangzhou Medical College, Guangzhou 510060, China) |
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| Abstract: | It has been documented that host factors, viral factors and other external factors acting on host and virus such as smoking, environmental pollution and co-infection with other viruses, affect the outcomes of chronic hepatitis C patients treated with interferon. Recent studies have shown that IL-28B polymorphisms of host are highly related to the treatment results. The relation of IL-28B polymorphisms and the response to interferon treatment in patients with chronic hepatitis C are reviewed in this paper. |
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| Keywords: | Polymorphisms,single nucleotide Interleukin-28B Hepatitis C Interferons |
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