血清超敏C反应蛋白检测在糖耐量减低及糖尿病患者中的临床意义

目的比较不同糖耐量受试者血清超敏C反应蛋白（hs-CRP）水平，探讨hs-CRP检测在糖耐量减低（IGT）及糖尿病患者中的作用。方法所有受试者均行口服葡萄糖耐量试验（OGTT），用免疫透射比浊法测定正常糖耐量（NGT）、IGT、2型糖尿病（T2DM）受试者血清hs-CRP水平。结果NGT、IGT和T2DM者血清hs-CRP水平分别为（1．57±0．46）、（2．84±0．48）、（4．18±0．76）mg／L，hs-CRP分别与体重指数、收缩压、舒张压、空腹血糖、OGTT试验中2h血糖、三酰甘油和总胆固醇呈正相关。结论T2DM患者早在IGT阶段就已经存在炎性反应，炎性反应可能参与了T2DM的发生和发展。hs-CRP作为炎性反应因子，在预测和监视T2DM方面有重要意义。

Clinical significance of serum high-sensitivity C-reactive protein in impaired glucose tolerance and diabetes mellitus

Objective To investigate the significance of serum high-sensitivity C-reactive protein （hs-CRP） concentration in subjects with various glucose tolerance and study the role of hs-CRP in patients of impaired glucose tolerance （IGT） and diabetes mellitus. Method All subjects in the study underwent oral glucose tolerance test （OGTT）. Determination of serum hs-CRP levels in normal glucose tolerance （NGT）, IGT and type 2 diabetes mellitus （T2DM） patients were made by immunologic projective turbidimetry method. Results The levels of serum hs-CRP were （ 1.57 ± 0.46） mg/L in NGT patients, （2.84 ± 0.48） mg/L in IGT patients, and （4.18 ± 0.76） mg/L in T2DM patients. The levels of serum hs-CRP were positively correlated with body mass index, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, OGTT 2 hPG, triglyceride, and total cholesterol. Conclusions Inflammation has already existed not only in T2DM patients but also in subjects with IGT. Inflammation might participate in the occurrance and development of T2DM. hs-CRP as an inflammator factor can be used to predict and monitor T2DM.