Resveratrol attenuates bone cancer pain through the inhibition of spinal glial activation and CX3CR1 upregulation |
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| Authors: | Wei Cheng Yu Zhao He Liu Qin Fan Fei‐Fei Lu Jing Li Qin Yin Chang‐Dong Yan |
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| Affiliation: | 1. Affiliated Hospital of Xuzhou Medical College, , Xuzhou, Jiangsu, 221002 China;2. Xuzhou medical College, , Xuzhou, 221002 China;3. Jiangsu Province Key Laboratory of Anesthesiology and Center for Pain Research and Treatment, Xuzhou Medical College, , Xuzhou, 221002 China |
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| Abstract: | The present study examined the effects of intrathecal use of resveratrol on pain hypersensitivities, spinal glia activation, and CX3CR1 expression in the model of bone cancer pain (BCP). The BCP model was established through intrathecally injecting Walker 256 mammary gland carcinoma cells to Sprague‐Dawley rats. We found that spinal CX3CR1 expression and glial activation aggravated after inoculation. Resveratrol (i.t.) attenuated bone cancer‐induced pain hypersensitivities, decreased CX3CR1 expression and glial activation in the spine in a BCP model. Resveratrol (i.t.) also attenuated mechanical allodynia resulting from intrathecally injecting fractalkine in rats. Inhibition of spinal glial activation and CX3CR1 upregulation may involve in resveratrol's analgesic effects. These findings demonstrated that resveratrol attenuated pain facilitation through inhibiting spinal glial activation and CX3CR1 upregulation in a BCP model. |
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| Keywords: | astrocytes bone cancer pain CX3CR1 microglia resveratrol |
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