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Emerging role of interleukin‐33 in autoimmune diseases |
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| Authors: | Cheng Pei Mark Barbour Karen J. Fairlie‐Clarke Debbie Allan Rong Mu Hui‐Rong Jiang |
| Affiliation: | 1. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, , Glasgow, UK;2. Department of Ophthalmology, First Affiliated Hospital of the Medical College, Xi'an Jiaotong University, , Xi'an, China;3. Institute of Rheumatology and Immunology, People's Hospital, Peking University, , Beijing, China |
| Abstract: | Interleukin‐33 (IL‐33) is a member of the IL‐1 cytokine family. It predominantly induces type 2 immune responses and thus is protective against atherosclerosis and nematode infections but contributes to allergic airway inflammation. Interleukin‐33 also plays a pivotal role in the development of many autoimmune diseases through mechanisms that are still not fully understood. In this review, we focus on the recent advances in understanding of the expression and function of IL‐33 in some autoimmune disorders, aiming to provide insight into its potential role in disease development. |
| Keywords: | autoimmune diseases inflammation interleukin‐33 ST2 |