Paeonol suppresses lipopolysaccharide‐induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock |
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| Authors: | Lanan Wassy Soromou Jingjing Sun Weiting Zhong Weixiao Guo Meixia Huo Hongyu Li Shuang Guan Zhenwen Chen Haihua Feng |
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| Institution: | 1. College of Animal Science and Veterinary Medicine, Jilin University, , Changchun, 130062 China;2. Department of Laboratory Animal Science, School of Basic Medical Science, Capital Medical University, , Beijing, 100069 China |
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| Abstract: | Paeonol (2′‐hydroxy‐4′‐methoxyacetophenone) is the main phenolic compound of the radix of Paeonia suffruticosa which has been used as traditional Chinese medicine. In this study, we primarily investigated the anti‐inflammatory effects and the underlying mechanisms of paeonol in RAW macrophage cells; and based on these effects, we assessed the protective effects of paeonol on lipopolysaccharide‐induced endotoxemia in mice. The in vitro study showed that paeonol regulated the production of TNF‐α, IL‐1β, IL‐6, and IL‐10 via inactivation of IκBα, ERK1/2, JNK, and p38 MAPK. In mouse model of lipopolysaccharide‐induced endotoxemia, pro‐ and anti‐inflammatory cytokines are significantly regulated, and thus the survival rates of lipolysaccharide‐challenged mice are improved by paeonol (150, 200, or 250 mg/kg). Therefore, paeonol has a beneficial activity against lipopolysaccharide‐induced inflammation in RAW 264.7 cell and mouse models. |
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| Keywords: | cytokines lipopolysaccharide paeonol pathway survival |
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