Gardner综合征(附一家族12例10年随访分析)

目的通过对一家族患Gardner综合征患者的10年追踪观察，了解本病的动态变化。方法一家族四代12例患者，男女各6例c.年龄最人者74岁，最小者9岁，平均38岁。检查方法采用结肠气钡双对比造影、纤维结肠镜、X线平片及人体实体摄影。结果出现三联症者8例（66.7％），出现二联症者4例（33.3％）．10年追踪观察，其中4例（33．3％）因结肠息肉发生癌变而死亡，息肉癌变的部位均发生在直肠与乙状结肠．死亡年龄最大74岁，最小35岁。结论本病结肠息肉癌变率很高，30岁以后即可发生，60岁以卜为高峰期.结肠息肉预防性切除仍是最好的治疗方法。

Gardner's syndrome: a ten year follow up survey of 12 subjects in a family

Purpose To study the development of Gaboner's syndrome by following up 12 subjects in a family for ten years. Methods 12 subjects with Gardner's syndrome of 4 generations in a family werestudied.Six were male and six female. The age of the patients was from 9 to 74 years, with average of 38 years. The examinations consisted of air-barium double contrast radiopophy of colon, fiber-optic colonoscopy, plain X-ray and body photography. Results Triology was present in 8 cases (66.7% ) and the double signs in 4 cases (33. 3 % ). 4 patients(33. 3 % )died of malignant degeneration of colonic polyp in 10 years, all occurring in rectum and sigmoid colon. the oldest one was 74 years and the youngest 35 years. Conclusion The incidence of malignant degeneration of colonic polyp is very high in patients with Gardner's syndrome and may occur in patients older than 30 years, with the peak incidence in the sixth decade. Preventive reception of colonic polyp is still the best treatment.