| E-钙黏蛋白在大肠癌中的表达及意义 |
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| 引用本文： | 林树森,王锡山,邹德龄,陈洪生,尤琦. E-钙黏蛋白在大肠癌中的表达及意义[J]. 哈尔滨医科大学学报, 2009, 43(6): 576-579 |
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| 作者姓名： | 林树森 王锡山 邹德龄 陈洪生 尤琦 |
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| 作者单位： | 哈尔滨医科大学第三临床医学院,结直肠外科,黑龙江,哈尔滨,150081;哈尔滨医科大学第三临床医学院,结直肠外科,黑龙江,哈尔滨,150081;哈尔滨医科大学第三临床医学院,结直肠外科,黑龙江,哈尔滨,150081;哈尔滨医科大学第三临床医学院,结直肠外科,黑龙江,哈尔滨,150081;哈尔滨医科大学第三临床医学院,结直肠外科,黑龙江,哈尔滨,150081 |
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| 摘 要： | 目的 探讨E-钙黏(E-cadherin,E-cad)蛋白表达与大肠癌的发生、发展及预后的关系.方法 利用免疫组化SP法,检测101例大肠癌原发灶、10例腺瘤及20例正常大肠黏膜组织中E-cad蛋白表达.结果 E-cad的低表达与肿瘤分期、分化,有无淋巴结转移及远处转移相关(P<0.05);与肿瘤组织类型、浸润深度、部位、大小以及性别和年龄无相关性(P>0.05);E-cad阳性表达组与阴性组之间比较,生存期无显著性差异(P>0.05).结论 大肠癌组织中E-cad低表达与大肠癌发生、发展、侵袭转移有关.
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| 关 键 词： | 结肠直肠肿瘤 E-钙黏蛋白 免疫组织化学 |
Expression and significance of E-cadherin protein in colorectal cancer |
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| Abstract: | Objective To investigate the correlation between the expression of E-cadherin(E-cad)protein and invasion,metastasis and prognosis in colorectal cancinoma(CRC).Methods The expression of E-cad protein were measured by immunohistochemistry in 101 specimens of CRC,10 specimens of colorectal adenoma and 20 specimens of normal tissues.Results The reduced-expression of E-cad protein was associated with Dukes stages and degree of differentiation,lymph nodes and distant organs metastasis(P<0.05);there was no correlation with types of neoplasms,depth of infiltration,location,size,gender and age(P>0.05).The difference of survival periods between positive and negative groups on E-cad protein was not signficant(P>0.05).Conclusion The reduced-expression of E-cad protein is closely associated with invasion and metastasis in colorectal cancer. |
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| Keywords: | colorectal neoplasm E-cadherin protein immunohistochemistry |
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