安宫牛黄丸对重症脑出血的临床疗效及安全性分析

目的：探讨安宫牛黄丸对重症脑出血患者的临床疗效及安全性，为临床治疗提供参考。方法：将本院治疗的53例重症脑出血患者随机分为治疗组28例和对照组25例，对照组进行常规治疗，治疗组在对照组基础上加用安宫牛黄丸；对比两组临床疗效、GCS评分、NIHSS评分、血清乳酸和CRP水平，并记录两组并发症发生率，综合评价两组对重症脑出血的效果。结果：治疗6周后，治疗组总有效率为82．14％，对照组为54．00％，治疗组明显高于对照组，两组相比，差异有统计学意义（P〈0．05）；治疗组治疗1周、2用、4周GCS评分和NIHSS评分均显著优于对照组（P〈0．05）；治疗组血清乳酸、CRP水平较对照组明显降低（P〈0．05）。此外治疗组肺部感染、肾功能损伤、便秘等不良反应发生率明显低于对照组（P〈0．05）。结论：重症脑出血在常规治疗基础上加用安宫牛黄丸，不仅提高临床疗效，还可以明显降低患者并发症发生率，值得临床推广应用。

Analysis on Clinical Efficacy and Safety of Angong Niuhuang Pill in Treatment of Patients with Severe Cerebral Hemorrhage

Objective： To explore the clinical efficacy and safety of Angong Niuhuang Pill in severe cerebral hemorrhage and to provide the reference for the clinical treatment. Methods ： 53 patients with severe cerebral hemorrhage treated in our hospital were randomized divided into observation groups with 28 cases and control group with 25 cases. The control group was given conventional treatment. The treatment group based on the control group used Angong Niuhuang pill. Two groups＇clinical curative effect, GCS score, NIHSS score, serum lactate and CRP levels were compared, and the two groups＇incidence of complications and comprehensive evaluation results of two groups were recorded. Results： After 6 weeks of treatment,the total effective rate of treatment group was 82.14%, and it was 54% in the control group and the treatment group was significantly superior to the control group with statistical difference （P 〈 0.05 ）. 1 week,2 weeks ,4 weeks after the treatment,the treatment group＇ s GCS score and NIHSS score were significantly better than those of the control group （ P 〈 0.05）. The serum lactic acid and CRP levels were significantly lower than those of the control group （P 〈 0.05 ）. In addition, the treatment group＇ s lung infection, renal injury, constipation and other adverse reaction inci- dence were significantly lower than those of the control group （P 〈 O. 05）. Conclusion ： On the basis of conventional therapy, Angong Niuhuang Pill in severe cerebral hemorrhage patients, can not only improve the clinical efficacy, but also significantly reduce the incidence of complications in patients, and it is worthy of clinical application.