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| 坎地沙坦酯片治疗原发性高血压118例 | |
| 引用本文： | 钱岳晟,王宪衍,黄高忠,陆凤翔,耿其吉,周和,朱鼎良.坎地沙坦酯片治疗原发性高血压118例[J].中国新药与临床杂志,2005,24(11):849-853. |
| 作者姓名： | 钱岳晟 王宪衍 黄高忠 陆凤翔 耿其吉 周和 朱鼎良 |
| 作者单位： | 1. 上海第二医科大学附属瑞金医院,上海市高血压研究所,上海,200025 2. 上海长征医院,上海,200002 3. 南京医科大学第一附属医院,江苏,南京,210029 4. 南京医科大学附属南京第一医院,江苏,南京,210006 5. 上海庆安药业有限公司,上海,200135 |
| 摘 要： | 目的:比较国产坎地沙坦酯片与氯沙坦治疗轻、中度原发性高血压的疗效和安全性。方法:多中心、随机、双盲、双模拟、阳性药平行对照试验。经2 wk安慰剂导入期,238例原发性高血压病人进入8 wk治疗期,每日1次服用坎地沙坦酯片8 mg(n=118),或氯沙坦片50 mg(n=120),2 wk后如舒张压≥12 kPa则剂量加倍。结果:2组病人的血压均得到明显地降低(P<0.01);坎地沙坦酯组总有效率为82.2%,氯沙坦组为84.2%,2组间没有显著差异。坎地沙坦酯组和氯沙坦组收缩压和舒张压的降压谷峰(T/P)比值分别为0.75,0.71和0.76,0.94。结论:对轻、中度原发性高血压病人坎地沙坦酯片是一种有效、安全且易耐受的降压药,每日1次能维持24 h降压效应。 |
| 关 键 词： | 高血压 坎地沙坦酯 坎地沙坦 氯沙坦 多中心研究 双盲法 随机对照试验 抗高血压药 |
| 文章编号： | 1007-7669（2005）11-0849-05 |
| 收稿时间： | 2004-09-03 |
| 修稿时间： | 2004-09-032005-09-10 |
Candesartan cilexetil in treatment of essential hypertension in 118 patients |
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| QIAN Yue-sheng,WANG Xian-yan,HUANG Gao-zhong,LU Feng-xiang,GENG Qi-ji,ZHOU He,ZHU Ding-liang.Candesartan cilexetil in treatment of essential hypertension in 118 patients[J].Chinese Journal of New Drugs and Clinical Remedies,2005,24(11):849-853. | |
| Authors: | QIAN Yue-sheng WANG Xian-yan HUANG Gao-zhong LU Feng-xiang GENG Qi-ji ZHOU He ZHU Ding-liang |
| Institution: | 1. Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Second Medical University, SHANGHAI 200025, China ; 2. Shanghai Changzheng Hospital, SHANGHAI 200002, China ; 3. The First Affiliated Hospital of Nanjing Medical University, Nanfing JIANG- SHU 210029, China; 4. The Nanjing First Affiliated Hospital of Nanfing Medical University, Nanfing JIAN- GSHU 210006, China ; 5. Shanghai Qing-an Pharma- ceuticals Limited, SHANGHAI 200135, China |
| Abstract: | AIM: To compare the efficacy and safety of candesartan cilexetil and losartan in the treatment of essential hypertension.METHODS: Following a 2 wk placebo period,238 patients were enrolled to a multiple-center,randomized,double-blind,double-simulate,parallel study with either candesartan cilexetil 8 mg(n=118) or losartan 50 mg(n=120) once daily for 8 wk.Dose doubling was carried out for those with diastolic blood pressure ≥12 kPa after 2 wk treatment.RESULTS: A significant reduction of blood pressure(SBP or DBP) was achieved in both groups(P<0.01).There was no significant difference in responder rates between candesartan cilexetil treated patients(82.2 %) and that of losartan treated patients(84.2 %). The tough to peak ratios of SBP and DBP were calculated as 0.75,0.71 for candesartan cilexetil and 0.76,0.94 for losartan.CONCLUSION: Candesartan cilexetil once daily is effective,safe and well tolerated in mild to moderate hypertension patients. |
| Keywords: | hypertension candesartan cilexetil candesartan losartan multicenter studies double-blind method randomized controlled trims antihyperteasive agents |
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