Health-related quality of life and sleep-disordered breathing in children

STUDY OBJECTIVES: To assess the extent to which sleep-disordered breathing (SDB) is associated with impairment of health-related quality of life (HRQOL) in children DESIGN: Observational study of pediatric participants in a longitudinal genetic-epidemiologic cohort study of SDB. SETTING: Community-based; studies conducted at participants' homes PARTICIPANTS: 298 children, aged 11.1 years +/- 3.5 SD; 54% females; 61% African-American or Other; 81% with a family member identified with laboratory-confirmed SDB. INTERVENTIONS: Not applicable MEASUREMENTS AND RESULTS: The HRQOL was assessed with the Child Health Questionnaire (CHQ-PF50), a 50-item parent-completed form that measures 14 multidimensional health concepts. Sleep-disordered breathing (SDB) was assessed with ovemight in-home monitoring that recorded nasal-oral airflow, pulse oximetry, chest-wall impedance, and heart rate. Using logistic regression analyses, each CHQ scale outcome was analyzed independently for the effect of SDB, adjusting for other potential confounding variables and for family-correlated data. Significant differences in overall physical health and complaints of bodily pain were observed in children with generally mild levels of SDB. Relationships persisted after adjustment for age, gender, ethnicity, obesity, and asthma. CONCLUSIONS: SDB in children is associated with measurably lower levels of specific dimensions of HRQOL in children. Decrements in HRQOL are measurable even for children with mild SDB, with increasing effects observed with more severe SDB.