| 舒筋灵对家兔溴氰菊酯静脉染毒的拮抗作用 |
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| 引用本文： | 唐玲芳,程健,冯致英,杨永年.舒筋灵对家兔溴氰菊酯静脉染毒的拮抗作用[J].南京医科大学学报,1990(2). |
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| 作者姓名： | 唐玲芳 程健 冯致英 杨永年 |
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| 作者单位： | 南京医学院卫生毒理学教研室，南京医学院卫生毒理学教研室，南京医学院卫生毒理学教研室，南京医学院卫生毒理学教研室 |
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| 摘 要： | 家兔静脉染毒溴氰菊酯所产生的急性毒性症状与大鼠相似,半数致死量为1.35mg/kg。家兔静脉染毒溴氰菊酯2.7mg/kg后立即静脉注射舒筋灵300mg/kg,可有效地拮抗溴氰菊酯的毒作用,缓解中毒症状,使家兔死亡率从100%降低至25%(P<0.05)。家兔溴氰菊酯2.15mg/kg静脉染毒后5分钟给予舒筋灵300mg/kg,可降低死亡率50%(P<0.05)。在染毒后10分钟给舒筋灵,舒筋灵已不能拮抗溴氰菊酯对家兔的毒作用。表明舒筋灵对以溴氰菊酯的拮抗作用只在溴氰菊酯的作用初期有效。
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| 关 键 词： | 舒筋灵 溴氰菊酯 兔 |
EFFECT OF METHOCARBAMOL ON INTRAVENOUS INJECTION OF DELTAMETHRIN IN RABBITS |
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| Tang Lingfang,et al..EFFECT OF METHOCARBAMOL ON INTRAVENOUS INJECTION OF DELTAMETHRIN IN RABBITS[J].Acta Universitatis Medicinalis Nanjing,1990(2). |
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| Authors: | Tang Lingfang |
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| Abstract: | The acute toxic symptoms produced by intravenously administered deltamethrin(DM)in rabbits were similar to those in rats,The median lethal dose of DM(i.v.)in rabbit was 1.35mg/kg.Methocarbamol(MC)(300mg/kg i.v.)given immediately following DM (2.7mg/kg i.v.)relieved the toxic symptoms in rabbits and decreased death rate by 75%.Rabbits received MC 10 minutes after DM administration all died,and the toxic symptoms of DM could not be lessened.The therapeutic effects of MC given five minutes after DM was apparently better than those given 10 minutes after DM.The results indicated that it is necessary to give MC as soon as possible after the administration of DM. |
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| Keywords: | methearbamol deltamethrin rabbit |
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