Association between intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid (n-3 PUFA DHA) and reduced risk of ovarian cancer: A systematic Mendelian Randomization study |
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| Affiliation: | 1. Department of Epidemiology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, 215123, China;2. Department of Toxicology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, 215123, China;3. National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, 215123, China;4. State Key Laboratory of Medical Molecular Biology, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, 215123, China;5. Biomedical Center, Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, 30605, Pilsen, Czech Republic;6. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany;7. Department of Oncology and Hematology, the Affiliated Suzhou Hospital of Nanjing University Medical School, Suzhou, 215153, China;8. Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, 215123, China;1. Edible Research Ltd, Ohoka, New Zealand;2. Department of Women''s and Children''s Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand;3. The Liggins Institute, The University of Auckland - Waipapa Taumata Rau, Auckland, New Zealand;1. Acıbadem Altunizade Hospital, Department of Nutrition and Dietetics, Istanbul, Turkiye;2. Istanbul Galata University, Department of Nutrition and Dietetics, School of Health Sciences, Istanbul, Turkiye;3. Acibadem Mehmet Ali Aydınlar University, Medical School, Radiation Oncology Department, Istanbul, Turkiye;4. Acibadem Altunizade Hospital, Radiation Oncology Department, Istanbul, Turkiye;1. Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Boston VA Healthcare System and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;2. First Department of Propaedeutic Internal Medicine, Laiko General Hospital, National and Kapodistrian University of Athens School of Medicine, Athens 11527, Greece;3. Diabetes and Obesity Unit, Athens Medical Center, Athens 15125, Greece;4. Ansh Labs, Webster, TX 77598, USA;1. Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands;2. Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands;3. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands |
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| Abstract: | |
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| Keywords: | Docosahexaenoic acid (DHA) Genome-wide association study (GWAS) Mendelian randomization (MR) n-3 polyunsaturated fatty acid (PUFA) Ovarian cancer CCOC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" clear cell ovarian cancer CI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" confidence interval DHA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" docosahexaenoic acid EOC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" endometrioid ovarian cancer GWAS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" genome-wide association study HGSOC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" high grade serous ovarian cancer IVW" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" inverse-variance weighted IV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" instrumental variable IMOC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" invasive mucinous ovarian cancer LGSOC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" low grade serous ovarian cancer MR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" Mendelian randomization OC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" ovarian cancer OR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" odds ratio PUFA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" polyunsaturated fatty acid SNP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" single nucleotide polymorphism SD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" standard deviation |
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