Population structure of Neisseria meningitidis ST-9493 identified in Colombian isolates |
| |
| Affiliation: | 1. Grupo de Microbiología, Instituto Nacional de Salud (INS), Bogotá, Colombia;2. Panamerican Health Organization/World Health Organization (PAHO/WHO);1. Microbiology Service, University Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain;2. Department of Molecular Biology, University of Cantabria, Santander, Spain;1. Servicio de Microbiología, Hospital Universitario Marqués de Valdecilla, Santander, Spain;2. IDIVAL, Santander, Spain;1. Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain;2. Medicine Department, Universitat Autònoma de Barcelona, Bellaterra, Spain;3. Infectious Diseases Department, Hospital Universitari de Bellvitge, Carrer de la Feixa Llarga, s/n, Barcelona, Spain;4. Spanish Network for the Study of Infectious Diseases (REIPI), Spain;5. Cardiology Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain;6. Radiology Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain;7. Nuclear Medicine Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain;8. Microbiology Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain;1. Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Spain;2. Unit of Immunology, Biochemistry, Molecular Biology and Surgery, Faculty of Medicine, Universidad de Málaga, Spain;3. Unit of Microbiology, Hospital General Universitario de Castellón, Spain;4. Unit of Medicine, Faculty of Medicine, Universidad de Sevilla, Spain;5. Instituto de Biomedicina de Sevilla (IBiS), Spain;6. CIBERINFEC;1. Service of Microbiology, University Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain;2. Department of Molecular Biology, University of Cantabria, Santander, Spain |
| |
| Abstract: | IntroductionNeisseria meningitidis is associated with invasive infections causing high mortality rates. The objective of this study was to describe the population structure of Colombian invasive isolates with ST-9493, a potentially emerging clonal group in the country.MethodsThe complete genomes of 34 invasive isolates of serogroup B with ST-9493 and its variants at one or two loci were sequenced by Illumina to describe the phenotypic and genotypic characteristics of these isolates.ResultsThe relationship of a clonal group associated with ST-136 CC41/44 was phylogenetically established, identifying two main clades composed of isolates from an outbreak or endemic. The most frequent alleles and peptides included porA 17, porB 44, fHbp 2.24, NHBA 10, and the FetA F5-17 variant. Most of the isolates were susceptible to the antibiotics evaluated.ConclusionThis study shows that meningococcal isolates with ST-9493 are an autochthonous clonal group with population dynamics and the capacity to cause endemic and epidemic meningococcal disease in Colombia. |
| |
| Keywords: | Serogroup B Clone Whole genome sequencing Multilocus sequence typing Serogrupo B Clon Secuenciación de genoma completo Tipificación multilocus de secuencias |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
