Acute reactions after a homologous primary COVID-19 vaccination series: Analysis of Taiwan V-Watch data |
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| Institution: | 1. Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan;2. Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan;3. Health Data Research Center, National Taiwan University, Taipei, Taiwan;4. Integrative Medical Database Center, Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan;5. Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan |
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| Abstract: | IntroductionThe ChAdOx1 nCoV-19 (ChAd), mRNA-1273 (m1273), MVC-COV1901 (MVC), and BNT162b2 (BNT) COVID-19 vaccines received authorization for emergency use in Taiwan beginning in February 2021. We investigated acute reactions to homologous primary COVID-19 vaccination series in adults aged ≥ 18 years.MethodsIn this prospective observational study based on smartphone data (Taiwan V-Watch), we calculated the frequencies of self-reported local and systemic acute reactions within 7 days of a COVID-19 vaccination, and the health effects up to 3 weeks after each dose. Those who reported adverse reactions after both doses were assessed by the McNemar test.ResultsDuring 22 March 2021–13 December 2021, 77,468 adults were enrolled; 59.0 % were female and 77.8 % were aged 18–49 years. For both doses of all four vaccines, the local and systemic reactions were minor in severity and highest on days 1 and 2 after vaccination, and declined markedly until day 7. For 65,367 participants who provided data after the first and second doses, systemic reactions were more frequent after dose 2 of the BNT and m1273 vaccines (McNemar tests: both p < 0.001), while local reactions were more frequent after dose 2 of the m1273 and MVC vaccines (both p < 0.001), compared with dose 1 of the homologous vaccine. Among the participants aged 18–49 years, the percentage who missed work on the day after vaccination was slightly higher among women (9.3 %) than among men (7.0 %).ConclusionsAcute reactogenicity and impact of work absenteeism for the four COVID vaccines in the V-Watch survey were mild and of short duration. |
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| Keywords: | Adverse reactions COVID-19 Vaccines Vaccine safety ChAd"} {"#name":"keyword" "$":{"id":"k0030"} "$$":[{"#name":"text" "_":"ChAdOx1 nCoV-19 m1273"} {"#name":"keyword" "$":{"id":"k0040"} "$$":[{"#name":"text" "_":"mRNA-127 MVC"} {"#name":"keyword" "$":{"id":"k0050"} "$$":[{"#name":"text" "_":"MVC-COV1901 BNT"} {"#name":"keyword" "$":{"id":"k0060"} "$$":[{"#name":"text" "_":"BNT162b2 COVID-19"} {"#name":"keyword" "$":{"id":"k0070"} "$$":[{"#name":"text" "_":"coronavirus disease 2019 EUA"} {"#name":"keyword" "$":{"id":"k0080"} "$$":[{"#name":"text" "_":"emergency use authorization WHO"} {"#name":"keyword" "$":{"id":"k0090"} "$$":[{"#name":"text" "_":"World Health Organization CDC"} {"#name":"keyword" "$":{"id":"k0100"} "$$":[{"#name":"text" "_":"Centers for Disease Control VAERS"} {"#name":"keyword" "$":{"id":"k0110"} "$$":[{"#name":"text" "_":"Vaccine Adverse Event Report System |
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