Parental acceptance of typhoid conjugate vaccine for children aged 6 months to 15 years in an outbreak setting of Lyari Town Karachi,Pakistan |
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| Institution: | 1. Department of Pediatrics and Child Health, Aga Khan University Hospital, Stadium Rd, PO Box 3500 Karachi 74800, Pakistan;2. Centre for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, Tampere 33520, Finland;3. The Kirby Institute, UNSW Sydney, Wallace Wurth Building High Street, UNSW Sydney, Kensington, NSW 2052, Australia |
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| Abstract: | BackgroundThis study aimed to evaluate the parental acceptance of Typhoid Conjugate Vaccine (TCV) and to determine the predictors of TCV vaccination status among children in an outbreak setting of extensively drug resistant (XDR) typhoid fever in Karachi, Pakistan.MethodsA cross-sectional survey using the WHO recommended rapid vaccine coverage assessment technique was conducted. Out of 11, four union councils (UCs) in Lyari Town were randomly selected. A parent or primary caretaker from the eligible household was interviewed. Data were collected using a locally validated vaccine attitudes scale (VAS). Sum of scores was calculated for VAS. A higher score denoted negative attitudes and perceptions regarding TCV and vice versa. Multivariable logistic regression was performed to determine the predictors of TCV vaccination status.ResultsBased on the 14-item parental VAS, 78.0 % of the parents had a score between 0 to <40 and 22 % had a score ≥40. VAS score of <40 was significantly associated with higher odds of receiving TCV during the campaign setting (adjusted Odds Ratio (aOR): 1.30; 95 % Confidence Interval (CI): 1.02, 1.66). The odds of receiving TCV vaccination were higher among children whose parents were aware of the ongoing vaccination campaign in the area (aOR: 4.57; 95 % CI: 2.93, 7.12) and expressed willingness to get their child vaccinated against typhoid fever (aOR: 2.54; 95 % CI: 1.82, 3.55).ConclusionParental awareness of the ongoing vaccination campaign, positive perception and attitudes towards vaccine were found to be significantly associated with TCV vaccination among children. Appropriately structured pre-vaccination awareness campaigns focused on childhood vaccination targeted towards parents are necessary to improve parental awareness, attitude and behavior towards vaccination. |
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| Keywords: | Outbreak Typhoid conjugate vaccine Cross-sectional study Parental acceptance Vaccine attitudes scale AMR"} {"#name":"keyword" "$":{"id":"k0035"} "$$":[{"#name":"text" "_":"antimicrobial resistance XDR"} {"#name":"keyword" "$":{"id":"k0045"} "$$":[{"#name":"text" "_":"extensively drug resistant TCV"} {"#name":"keyword" "$":{"id":"k0055"} "$$":[{"#name":"text" "_":"Typhoid Conjugate Vaccine UC"} {"#name":"keyword" "$":{"id":"k0065"} "$$":[{"#name":"text" "_":"Union Council VAS"} {"#name":"keyword" "$":{"id":"k0075"} "$$":[{"#name":"text" "_":"vaccine attitudes scale WHO"} {"#name":"keyword" "$":{"id":"k0085"} "$$":[{"#name":"text" "_":"World Health Organization GAVI"} {"#name":"keyword" "$":{"id":"k0095"} "$$":[{"#name":"text" "_":"Global Alliance for Vaccines and Immunization |
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