Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas
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Authors: | Gabriela da Silva Cruz Ana Luiza Dias Angelo Ticiana Ferreira Larocca Carolina Thé Macedo Márcia Noya- Rabelo Luís Claudio Lemos Correia Jorge Andion Torre?o Bruno Solano de Freitas Souza Ricardo Ribeiro dos Santos Milena Botelho Pereira Soares |
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Institution: | 1.Centro de Biotecnologia e Terapia Celular – Hospital São Rafael, Salvador, BA - Brazil;2.Departamento de Cardiologia - Hospital São Rafael, Salvador, BA - Brazil;3.Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Salvador, BA - Brazil |
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Abstract: | BackgroundGalectin-3, a β-galactoside binding lectin, has been described as a mediator of
cardiac fibrosis in experimental studies and as a risk factor associated with
cardiovascular events in subjects with heart failure. Previous studies have
evaluated the genetic susceptibility to Chagas disease in humans, including the
polymorphisms of cytokine genes, demonstrating correlations between the genetic
polymorphism and cardiomyopathy development in the chronic phase. However, the
relationship between the galectin-3 single nucleotide polymorphism (SNP) and
phenotypic variations in Chagas disease has not been evaluated.ObjectiveThe present study aimed to determine whether genetic polymorphisms of galectin-3
may predispose to the development of cardiac forms of Chagas disease.MethodsFifty-five subjects with Chagas disease were enrolled in this observational study.
Real-time polymerase chain reaction (PCR) was used for genotyping the variants
rs4644 and rs4652 of the galectin-3 gene.ResultsFor the SNP rs4644, the relative risk for the cardiac form was not associated with
the genotypes AA (OR = 0.79, p = 0.759), AC (OR = 4.38, p = 0.058), or CC (OR =
0.39, p = 0.127). Similarly, for the SNP rs4652, no association was found between
the genotypes AA (OR = 0.64, p = 0.571), AC (OR = 2.85, p = 0.105), or CC (OR =
0.49, p = 0.227) and the cardiac form of the disease.ConclusionOur results showed no association between the different genotypes for both SNPs of
the galectin-3 gene and the cardiac form of Chagas disease. |
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Keywords: | Chagas Disease Galectin 3 Heart Failure Polymorphism Genetic Chagas Cardiomyopathy |
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