Comparison of the EUCAST and CLSI Broth Microdilution Methods for Testing Isavuconazole,Posaconazole, and Amphotericin B against Molecularly Identified Mucorales Species |
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| Authors: | Anuradha Chowdhary Pradeep Kumar Singh Shallu Kathuria Ferry Hagen Jacques F. Meis |
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| Affiliation: | aDepartment of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India;bDepartment of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands;cDepartment of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands |
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| Abstract: | We compared EUCAST and CLSI antifungal susceptibility testing (AFST) methods for triazoles and amphotericin B against 124 clinical Mucorales isolates. The EUCAST method yielded MIC values 1- to 3-fold dilutions higher than those of the CLSI method for amphotericin B. The essential agreements between the two methods for triazoles were high, i.e., 99.1% (voriconazole), 98.3% (isavuconazole), and 87% (posaconazole), whereas it was significantly lower for amphotericin B (66.1%). Strategies for harmonization of the two methods for Mucorales AFST are warranted. |
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