| (E)-4-溴-3-甲基-2-丁烯酸的合成工艺改进 |
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| 引用本文： | 楚勇,路良,陈芬儿. (E)-4-溴-3-甲基-2-丁烯酸的合成工艺改进[J]. 中国药物化学杂志, 2005, 15(1): 51-52 |
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| 作者姓名： | 楚勇 路良 陈芬儿 |
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| 作者单位： | 复旦大学,化学系,上海,200433 |
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| 摘 要： | 以3-甲基-2-丁烯酸为起始原料,经硅酯化和溴代后,再将(Z)-4-溴-3-甲基-2-丁烯酸硅酯转化成相应内酯,从而经蒸馏分离出其反式异构体(E)-4-溴-3-甲基-2-丁烯酸硅酯,水解后即生成(E)-4-溴-3-甲基-2-丁烯酸,总收率为29%.
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| 关 键 词： | 药物化学 工艺改进 化学合成 (E)-4-溴-3-甲基-2-丁烯酸 3-甲基-2-丁烯酸 |
Improved synthesis of (E)-4-bromo-3-methyl-2-butenoic acid |
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| CHU Yong,LU Liang,CHEN Fen-Er. Improved synthesis of (E)-4-bromo-3-methyl-2-butenoic acid[J]. Chinese Journal of Medicinal Chemistry, 2005, 15(1): 51-52 |
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| Authors: | CHU Yong LU Liang CHEN Fen-Er |
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| Abstract: | E)-4-bromo-3-methyl-2-butenoic acid was conveniently synthesized from 3-methyl-2-butenoic acid in 29% overall yield.In this procedure,the title compound was easily obtained by hydrolysis of (E)-trimethylsilyl 4-bromo-3-methyl-2-butenoate,which could be isolated from its mixture of Z-/E-isomer by distillation in vacuo.The isomeric mixture was prepared via the esterification of 3-methyl-2-butenoic acid with chlorotrimethylsilane,followed by bromination with NBS. |
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| Keywords: | medicinal chemistry technics development chemical synthesis (E)-4-bromo-3-methyl-2-butenoic acid 3-methyl-2-butenoic acid |
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