Low Levels of Serum Apolipoprotein AI and AII in Senile Dementia |
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| Authors: | Masaru Kuriyama M.D. Kanehisa Takahashi M.D. Takashi Yamano M.D. Yoichi Hokezu M.D. Seiji Togo M.D. Mitsuhiro Osame M.D. Takeshi Igakura M.D. |
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| Affiliation: | The Third Department of Internal Medicine, Kagoshima University School of Medicine, Kagoshima;*Division of Neurology, Pearlland Hospital, Kagoshima |
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| Abstract: | Abstract: We studied the serum lipoprotein and apolipoprotein profiles in 44 patients with sporadic late-onset Alzheimer's dementia and 43 patients with vascular dementia. The levels of high-density lipoprotein (HDL) cholesterol were lower in both patient groups than in a control group. Apolipoprotein A I and A II levels have decreased in both the patient groups, especially in the vascular dementia group. The HDL-cholesterol levels correlated positively with the level of apolipoprotein A I, but not with the level of apolipoprotein A II. The ratios of apolipoprotein A I/A II have increased in both the patient groups. The apolipoprotein A II levels have disproportionally decreased in the patient groups. The serum apolipoprotein A II may involve the pathological process in the patients with senile dementia. |
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| Keywords: | Alzheimer's dementia vascular dementia apolipoprotein A I Apolipoprotein A II high-density lipoprotein |
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