| 激活AMPA受体抑制大鼠骶髓后连合核神经元NMDA反应──制霉菌素穿孔法膜片钳研究 |
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| 引用本文： | 徐天乐,赤池纪生. 激活AMPA受体抑制大鼠骶髓后连合核神经元NMDA反应──制霉菌素穿孔法膜片钳研究[J]. 神经解剖学杂志, 1996, 0(4) |
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| 作者姓名： | 徐天乐 赤池纪生 |
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| 作者单位： | 九州大学医学部生理学第二教室 |
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| 摘 要： | 在急性分离的大鼠骶髓后连合核神经元上，采用制霉菌素穿孔法膜片钳技术，研究ＡＭＰＡ受体和ＮＭＤＡ受体的相互作用．结果显示，激活ＡＭＰＡ受体可逆性地抑制ＮＭＤＡ反应，该效应依赖于细胞外钙离子．而且，通过ＡＭＰＡ受体通道内流的钙离子单独即足以抑制ＮＭＤＡ受体介导的反应．本结果证明，钙离子可透性ＡＭＰＡ受体可能参与了脊髓伤害性信息的调控．该过程可能与针刺镇痛的机制有关．
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| 关 键 词： | AMPA，NMDA，骶髓后连合核，钙离子，针刺镇痛 |
SUPPRESSION OF NMDA RESPONSE IN RAT SACRAL DORSAL COMMISSURAL NEURONS BY AMPA RECEPTOR ACTIVATION: A STUDY BY THE NYSTATIN PERFORATED PATCH TECHNIQUE |
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| Xu Tianle, Norio Akaike. SUPPRESSION OF NMDA RESPONSE IN RAT SACRAL DORSAL COMMISSURAL NEURONS BY AMPA RECEPTOR ACTIVATION: A STUDY BY THE NYSTATIN PERFORATED PATCH TECHNIQUE[J]. Chinese Journal of Neuroanatomy, 1996, 0(4) |
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| Authors: | Xu Tianle Norio Akaike |
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| Abstract: | The interactions between α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA ) and Nmethyl-D-aspertate(NMDA) receptors were studied in neurons acutely dissociated from rat sacral dorsal commissural nucleus (SDCN)using nystatin perforated whole-cell patch recording Configuration under voltage-clamp condition. AMPA receptor activation was found to induce reversible inhibition of NMDA response in a manner dependent on the extracellular Ca2+ Furthermore, Ca2+ entry through the AMPA receptor channels alone is sufficientfor the inhibition of NMDA receptor-mediated response. The present results provide the evidence that the Ca2+permeable AMPA receptors might be involved in modulation of spinal nociception. Such a process might be relatedto the mechanism of acupuncture analgesia. |
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| Keywords: | AMPA NMDA sacral dorsal commissural nucleus calcium acupuncture analgesia |
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