Neuronal responses in monkey lateral hypothalamus during operant feeding behavior |
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| Authors: | M Fukuda T Ono H Nishino K Nakamura |
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| Institution: | 1. Université Tunis El Manar, Faculté des Sciences de Tunis, Département de Physique, LR99ES13 Laboratoire de Physique de la Matière Condensée (LPMC), Tunis, Tunisie, 2092 Tunisia;2. Laboratoire de Magnétisme et Spectroscopie des Solides (LM2S), Département de Physique, Faculté des Sciences, Université Badji Mokhtar, Annaba B.P. 12, Annaba, 23000 Algeria;1. Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;2. Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;3. Department of Pharmacology, University of North Carolina at Chapel Hill, , Chapel Hill, North Carolina;4. Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;1. Molecular, Structural and Computational Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, 2010, Australia;2. Faculty of Medicine, University of New South Wales, Kensington, NSW, 2052, Australia;3. Brain and Mind Research Institute, University of Sydney, Sydney, NSW, 2006, Australia;4. Faculty of Engineering and Information Technology, Centre of Health Technologies, University of Technology Sydney, Ultimo, NSW, 2007, Australia;5. Cellular and Molecular Metabolism Laboratory, Baker IDI Diabetes and Heart Research Institute, Melbourne, VIC, 3004, Australia;6. Children''s Hospital Oakland Research Institute, Oakland, CA, 94609, USA;7. Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia |
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| Abstract: | Single neuron activity was recorded from monkey lateral hypothalamus to investigate neuronal events correlated with operant bar press feeding behavior. The behavioral paradigm was divided into three phase: visual (discrimination), bar press (procurement), and ingestion (consummatory). Of 669 neurons tested, 158 (24%) responded in one or more phases. During the visual phase, 106 neurons (16%) responded. Of 80 neurons that responded in the visual phase and were tested systematically, 33 (41%, 33/80) responded selectively to the sight of food or nonfood objects associated with a juice reward, but not to the sight of nonfood or objects associated with aversive saline. Neuronal activity related to discrimination was modulated by satiation and learning (i.e., acquisition and extinction). During the bar press phase, 51 neurons (7.6%) responded. These responded tonically during the early or late stage of the bar press period, but did not depend on individual bar pressing motions. During ingestion, 90 neurons (13%) responded. The ingestion response was modulated by palatability of food and satiation. Data suggest that the LHA is deeply involved in operant feeding behavior; discrimination of food, drive to get food, and perception of reward, all of which are affected by learning and internal states such as hunger and satiety. |
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