| 非甾体抗炎药物纳米递送系统研究进展 |
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| 引用本文： | 李东升, 郑辉利, 刘刚. 非甾体抗炎药物纳米递送系统研究进展[J]. 药学进展, 2021, 45(4): 243-253. |
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| 作者姓名： | 李东升 郑辉利 刘刚 |
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| 作者单位： | 1.厦门大学公共卫生学院分子影像暨转化医学研究中心, 福建 厦门 361102 |
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| 摘 要： | 非甾体抗炎药是使用最广泛的处方药之一，但长期使用会引起许多不良反应。与传统制剂相比，非甾体抗炎药纳米制剂能够改善药物溶解度，降低毒性，提高生物利用度。此外，纳米递送系统能够控制负载的非甾体抗炎药的释放，并在疾病模型中增强药物的治疗效果。综述脂质-囊泡纳米载体、聚合物纳米载体以及无机纳米载体在非甾体抗炎药物递送中的研究进展。
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| 关 键 词： | 非甾体抗炎药 纳米递送系统 纳米载体 |
| 收稿时间： | 2020-05-29 |
Progress in Research on Nano-delivery System for Non-steroidal Anti-inflammatory Drugs |
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| LI Dongsheng, ZHENG Huili, LIU Gang. Progress in Research on Nano-delivery System for Non-steroidal Anti-inflammatory Drugs[J]. Progress in Pharmaceutical Sciences, 2021, 45(4): 243-253. |
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| Authors: | LI Dongsheng ZHENG Huili LIU Gang |
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| Affiliation: | 1.Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China |
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| Abstract: | Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs, but their long-term use can cause many adverse reactions. Compared to conventional formulations, nano-formulations of NSAIDs can improve drug solubility, reduce toxicity, and enhance bioavailability. Furthermore, nano-delivery systems can sustain the release of the loaded NSAIDs and ameliorate the therapeutic efficacy of the drug in the disease model. This review systematically summarizes the recent progress in nano-delivery systems for NSAIDs, including lipid-vesicles nanocarriers, polymer nanocarriers and inorganic nanocarriers. |
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| Keywords: | non-steroidal anti-inflammatory drug nano-delivery system nanocarrier |
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