CCL2和CCR2在唾液腺腺样囊性癌中的表达及意义

目的 研究CCL2和CCR2在唾液腺腺样囊性癌（salivary adenoid cystic carcinoma, SACC）中的表达及其与临床病理特点之间的关系。方法 采用免疫组织化学染色方法检测CCL2、CCR2在60例SACC及12例正常唾液腺组织中的表达情况,并分析其与临床病理特征之间的关系。采用 SPSS 19.0软件包对实验结果进行统计学分析。结果 与正常唾液腺组织相比,CCL2和CCR2在 SACC组织中均呈现高表达,阳性表达率分别为91.7%和88.3%。CCL2和CCR2的表达与肿瘤临床分期、神经侵袭、肿瘤转移显著相关（P<0.05）;与性别、年龄、病理分型无显著相关性（P>0.05）。结论 CCL2、CCR2的表达与SACC的临床病理特征密切相关,检测两者的表达对SACC的诊断和临床病理研究具有重要的参考价值。

Expression and clinical significance of CCL2 and CCR2 in salivary adenoid cystic carcinoma

PURPOSE: To investigate the expression of CCL2 and CCR2 in salivary adenoid cystic carcinoma (SACC) and to find out its correlation with clinicopathological characteristics. Methods: Immunohistochemical staining was used to detect the expression of CCL2 and CCR2 in 60 primary SACC cases and 12 normal salivary gland tissues and analyze the correlation with clinicopathological characteristics. The results and clinicopathological data were statistically analyzed by SPSS 17.0 software package with χ² test, Wilcoxon rank sum test, and Spearman's rank correlation coefficient test. Results: High expression of CCL2(91.7%) and CCR2 (88.3%) was found in SACC cases compared with normal ones. The expression of CCL2 and CCR2 was significantly associated with histopathological stages, perineural invasion and distant metastasis (P<0.05), but there was no significant correlation with age, sex, and clinical stages (P>0.05). Conclusions: The expression of CCL2 and CCR2 is closely associated with clinicopathological characteristics of SACC. Detection of the expression of CCL2 and CCR2 may have great value in the diagnosis and clinicopathlogical study.