加巴喷丁治疗奥氮平所致不宁腿综合征2例并文献复习

目的探讨加巴喷丁治疗奥氮平所致不宁腿综合征(restless legs syndrome,RLS)的有效性。方法回顾性分析2例加巴喷丁治疗奥氮平所致RLS患者的临床资料及诊疗经过,并对相关文献进行复习。结果2例精神分裂症患者均在应用奥氮平治疗期间出现夜间双下肢难以形容的不适,控制不住地想要活动双腿,并起床走动,否则周身不适,难以入睡,用手拍打下肢或下床走动可减轻不适。诊断奥氮平所致RLS,应用加巴喷丁治疗后取得较好疗效。结论加巴喷丁可用于奥氮平所致RLS的治疗。

Gabapentin treatment in olanzapine-induced restless legs syndrome: Two cases report and literature review

Objective To explore the therapeutic efficacy of gabapentin on olanzapine-induced restless legs syndrome (RLS). Methods The clinical data, diagnosis and treatment of 2 cases of olanzapine-induced RLS treated with gabapentin were analyzed retrospectively, and the related literatures were reviewed. Results During the treatment with olanzapine, two patients with schizophrenia both suffered from unspeakable discomfort in their lower limbs at night. They uncontrollably wanted to move their legs and got up and walked, otherwise they would feel uncomfortable and difficult to fall asleep. Patting with their hands or walking out of bed could alleviate the discomfort. They were diagnosed as olanzapine-induced RLS and successfully treated with gabapentin. Conclusion Gabapentin can be used to treat olanzapine-induced RLS.