| 口腔微生物与炎症性肠病的关系 |
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| 引用本文： | 张浩楠,周学东,徐欣,王艳. 口腔微生物与炎症性肠病的关系[J]. 华西口腔医学杂志, 2019, 37(4): 443-449. DOI: 10.7518/hxkq.2019.04.020 |
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| 作者姓名： | 张浩楠 周学东 徐欣 王艳 |
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| 作者单位： | 口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科;口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院儿童口腔科,成都,610041 |
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| 基金项目： | 国家自然科学基金(81600864);国家自然科学基金(81771099);国家自然科学基金(81670978);四川省科技厅重大前沿项目(2016JY0006) |
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| 摘 要： | 炎症性肠病（IBD）是一种发病率高但治疗效果欠佳的特发性肠道炎症性疾病。目前认为IBD是环境因素、肠道菌群、个体易感性之间复杂作用的结果。近年来鉴于IBD患者的一系列口腔表征以及口腔微生物在IBD患者体内的高检出率,不少学者认为口腔微生物可能在IBD的发生发展中扮演了重要角色。本文就口腔微生物与IBD的关系研究进展作一综述。
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| 关 键 词： | 炎症性肠病 口腔微生物 溃疡性结肠炎 克隆恩病 |
| 收稿时间： | 2018-03-20 |
| 修稿时间： | 2019-04-18 |
Oral microbiota and inflammatory bowel disease |
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| Haonan Zhang,Xuedong Zhou,Xin Xu,Yan Wang. Oral microbiota and inflammatory bowel disease[J]. West China journal of stomatology, 2019, 37(4): 443-449. DOI: 10.7518/hxkq.2019.04.020 |
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| Authors: | Haonan Zhang Xuedong Zhou Xin Xu Yan Wang |
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| Affiliation: | 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China |
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| Abstract: | Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract with a high incidence but a poor therapeutic outcome. However, IBD is generally caused by complicated interactions between environmental factors and gut microflora in genetically susceptible individuals. In view of a series of oral manifestations in patients with IBD and a high detection rate of oral bacteria among this population, oral microbiota may play an important role in the development of IBD. This article reviews the relationship between oral microbiota and IBD. |
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| Keywords: | inflammatory bowel disease,oral microbiota,ulcerative colitis,Crohn’s disease , |
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