口腔种植修复对牙列缺失患者生活质量及龈沟液AST、OPN水平的影响

目的: 探讨口腔种植修复与常规修复对牙列缺失患者生活质量及龈沟液天冬氨酸转氨酶（aspartate amino transferase,AST）、骨桥蛋白（osteopontin ,OPN）水平的影响。方法: 前瞻性选择2016年10月—2018年10月解放军中部战区总医院汉口院区口腔科收治的牙列缺失患者106例,采用随机数字表法将患者分为2组,实验组（53例）采用口腔种植修复治疗,对照组（53例）采用常规修复治疗。观察2组疗效以及患者生活质量、龈沟液AST、OPN水平的差异。采用SPSS 25.0 软件包对数据进行统计学分析。结果: 实验组总治疗有效率90.57%,显著高于对照组（P<0.05）。实验组治疗后龈沟液AST、OPN水平显著低于对照组（P<0.05）。实验组治疗后OHIP-14评分中,功能受限、生理性疼痛、心理不适、生理障碍、心理障碍、社会障碍、残疾评分均显著低于对照组（P<0.05）。结论: 口腔种植修复可明显改善牙列缺失患者的生活质量,对龈沟液AST和OPN水平影响较小。

Impact of restoration on the quality of life of patients with dentition loss and AST and OPN levels of gingival crevicular fluid

PURPOSE: To investigate the effect of dental implant prosthesis and conventional prosthesis on the quality of life and the levels of aspartate aminotransferase (AST) and osteopontin (OPN) in gingival crevicular fluid of patients with dentition loss. METHODS: One hundred and six patients with dentition defect were prospectively selected from October 2016 to October 2018 in the Department of Stomatology, Hankou Branch of General Hospital of Central Theater Command. The patients were divided into two groups by random number table method. Patients in the experimental group (53 cases) were treated with dental implant prosthesis, while patients in the control group (53 cases) were treated with conventional prosthodontics. The curative effect, quality of life, AST and OPN levels in gingival crevicular fluid of the patients were observed. SPSS 25.0 software package was used to analyze the data. RESULTS: The total effective rate of the experimental group was 90.57%, which were significantly higher than that of the control group (P<0.05). After treatment, the AST and OPN levels in gingival crevicular fluid in the experimental group were significantly lower than those in the control group (P<0.05). After treatment, the OHIP-14 scores of the experimental group were significantly lower than those of the control group in terms of functional limitation, physiological pain, psychological discomfort, physiological disorder, psychological disorder, social disorder and disability (P<0.05). CONCLUSIONS: Dental implant prosthesis can significantly improve the quality of life of patients with dentition loss, and has little impact on the levels of AST and OPN in gingival crevicular fluid.