PET分子显像技术在药代动力学研究中的应用

药代动力学是药理学研究的重要内容之一，对于指导临床合理用药、预防药物不良反应、探究药物的作用机制和药物相互作用等具有重要意义。PET分子显像技术可以动态监测体内生理、生化等过程，可应用于血浆药代动力学、药物组织分布以及药物相互作用等研究，可缩短新药研发周期。笔者对近年来PET分子显像技术用于药代动力学的各个方面研究进行综述。

Application of PET molecular imaging technology to pharmacokinetics

Pharmacokinetics is an important part of pharmacology, which is guide for drug using rationally, preventing adverse reactions, studying the mechanism of action and drug-drug interaction. PET molecular imaging technology is able to dynamically monitor physiological, biochemical and biological processes in vivo, and it can be applied to the study of pharmacokinetics, tissues distribution and drug-drug interaction. All of these will promote new drug development. This paper summarizes the applications of PET molecular imaging technology to pharmacokinetics in recent years.