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Future Directions of Genomics Research in Rheumatic Diseases
Affiliation:1. Department of Statistical Genetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;2. Department of Otorhinolaryngology, Head and Neck Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;3. Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;4. Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan;5. Pharmaceutical Discovery Research Laboratories, Teijin Pharma Limited, 4-3-2, Asahigaoka, Hino-shi, Tokyo 191-8512, Japan;2. Carolina Population Center;3. Department of Biostatistics;4. Department of Medicine;5. Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;11. Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas;12. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington;8. Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center and;9. Department of Internal Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston Salem, North Carolina;112. Department of Medicine, Northwestern University Feinberg School of Medicine and;123. Department of Statistics and Biostatistics and;84. Department of Genetics, Rutgers University, Piscataway, New Jersey;95. Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and;1111. Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland;1212. Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia;88. National Institutes of Health, National Human Genome Research Institute, Office of Population Genomics, Bethesda, Maryland;99. Genetics and Genomic Sciences, The Charles Bronfman Institute for Personalized Medicine, The Center for Statistical Genetics, and The Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York;11112. Department of Preventive Medicine, Keck School of Medicine and;12123. Norris Comprehensive Cancer Center, University of Southern California, Pasadena, California;884. Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio;1. Laboratory of Molecular Genetics, Immunology and Biotechnology, Biology Department, Sciences Faculty of Tunisia, Campus University, 2092 El Manar, Tunis, Tunisia;2. Laboratory of Genetics and Vegetal Biotechnology, Biology Department, Sciences and Technics Faculty, University of Sultan Moulay Slimane, Beni-Mellal, Morocco;1. Immunology Graduate Program, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA;2. Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA;3. Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA;4. Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA;5. Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USA;6. Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA;7. Joint Molecular Rheumatology Laboratory, Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine in collaboration with Shanghai Institutes for Biological Sciences and Chinese Academy of Sciences, Shanghai 200031, PRC;8. Center for Immunity and Immunotherapies, Seattle Children’s Research Institute, Seattle, WA 98101, USA;9. Division of Rheumatology, Department of Pediatrics, University of Washington, Seattle, WA 98195, USA;10. Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USA;11. Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA;12. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA;13. Division of Rheumatology, Medical University of South Carolina, Charleston, SC 29425, USA;14. Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA;15. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA;16. Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA;17. Center for Autoimmune Diseases Research, Universidad del Rosario, 110010 Bogota, Colombia;18. Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA;19. Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94117, USA;20. Division of Rheumatology, Department of Medicine, School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA;21. Center for Genomics and Oncological Research, Pfizer-University of Granada-Junta de Andalucia, Granada 18016, Spain;22. Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA;23. Oklahoma City Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA;24. Division of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA;25. Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, Korea;26. Division of Rheumatology, School of Medicine, University of Colorado, Aurora, CO 80045, USA;27. Divisions of Genetics and Molecular Medicine and Immunology, King’s College London, Strand, London WC2R 2LS, UK;28. Cancer Biology, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA;29. Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA;1. Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands;2. Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands;3. Department for Health Evidence, Radboud University Medical Center, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands;4. Department of General Internal Medicine, Radboud University Medical Center, Geert Grooteplein 8, 6525 GA Nijmegen, The Netherlands;1. University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal;2. Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal;3. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal;4. Department of Biology, CIBIO – Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal;5. Department of Biology and Environment – CITAB, Botanical Garden and Herbarium, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal;6. Evolution, Taxonomy and Conservation Group (ECOMED), Department of Botany, University of Salamanca, E-37008 Salamanca, Spain
Abstract:
Keywords:Human genetics  Statistical genetics  Genome-wide association study  Next-generation sequencing  Human leukocyte antigen
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