SPECT定量心肌血流及冠状动脉血流储备的研究进展

应用SPECT、单光子显像剂及示踪动力学技术能方便地定量心肌血流量（MBF）及冠状动脉血流储备（CFR）。特别是碲锌镉心脏专用SPECT的使用，能更快速、准确地获得定量结果。MBF、CFR的获得对冠心病诊断准确性的提高、患者的再分层及进一步预后评估具有重要意义，并且为冠状动脉微血管疾病的诊断提供客观依据。但是使用SPECT定量MBF及CFR仍存在一些不足之处尚待解决。笔者旨在对SPECT定量MBF及CFR的不同方法、初步应用结果及临床意义作一综述。

Research progress of quantifying myocardial flow and coronary flow reserve with SPECT

Quantitative measurement of myocardial blood flow (MBF) and coronary flow reserve (CFR) can be derived from myocardial perfusion imaging by using SPECT, single-photon tracers, and tracer kinetic techniques. The use of cadmium zinc telluride cadmium heart dedicated SPECT (CZT SPECT) enables faster and more accurate quantitative results. The determination of MBF and CFR is of great significance for improving the accuracy of coronary heart disease (CAD) diagnosis, re-stratification of CAD patients, and further prognosis evaluation. It can also provide an objective way for diagnosing coronary microvascular disease. However, some deficiencies need to be addressed. This article reviewed the different methods, preliminary results, and clinical significance of quantifying MBF and CFR with SPECT.