| CAR-T细胞治疗实体瘤的归巢障碍及解决方法 |
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| 引用本文： | 杨松林,李琳,段德仁,侯宗柳,谭晶.CAR-T细胞治疗实体瘤的归巢障碍及解决方法[J].中国肿瘤临床,2019,46(14):755-759. |
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| 作者姓名： | 杨松林 李琳 段德仁 侯宗柳 谭晶 |
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| 作者单位： | 昆明医科大学附属延安医院, 云南省肿瘤免疫防治重点实验室(昆明市 650051) |
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| 基金项目： | 云南省科技计划项目2017IB020云南省科技计划项目2017IB005 |
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| 摘 要： | 嵌合抗原受体T(chimeric antigen receptor T，CAR-T)细胞治疗为一种新兴的免疫治疗，已在血液肿瘤治疗方面取得较大突破。但在实体瘤治疗方面却进展甚微，可能与CAR-T细胞在治疗实体瘤过程中难以有效归巢到肿瘤组织有关。实体瘤中复杂的肿瘤微环境以及肿瘤组织的屏障作用使CAR-T细胞无法和肿瘤细胞直接接触，从而无法发挥其抗肿瘤活性。本文就CAR-T细胞在治疗实体瘤中的归巢障碍及克服归巢障碍的方法进行综述。
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| 关 键 词： | 嵌合抗原受体T细胞 归巢 实体瘤 |
| 收稿时间： | 2019-05-31 |
Homing barriers and solutions for CAR-T cells in the treatment of solid tumors |
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| Institution: | Yan'an Affiliated Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming 650051, China |
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| Abstract: | Chimeric antigen receptor T (CAR-T) cell therapy is an emerging immunotherapy that has allowed for major breakthroughs in the treatment of hematological neoplasms. However, little progress has been made in the treatment of solid tumors, primarily due to the difficulty in homing to tumor tissues by CAR-T cells during treatment. The complex tumor microenvironment and the barrier function of tumor tissues prevent CAR-T cells from contacting tumor cells, thereby preventing them from exerting their antitumor activity. This review article summarizes not only the progress made in the study of homing disorders of CAR-T cells in the treatment of solid tumors but also the current methods to overcome these disorders. |
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