原发不明的颈部转移性癌的诊治进展

原发不明的颈部转移性癌（metastatic cervical carcinoma with an unknown primary，MCCUP）是一类异质性的临床综合征。通过分析现有数据资料，阐述其诊断和治疗进展。PET/CT在探寻原发肿瘤病变方面有较高的诊断价值。内镜和分子生物学技术如miRNA分子表达谱分析、微卫星分析的应用也提高了MCCUP的诊断水平。手术和放射治疗是最主要的治疗方式，大部分医师赞成对于小于N₂期的患者首选手术治疗。放疗仍占据重要地位，逆向调强放射治疗技术是治疗MCCUP的主流技术。

Diagnosis and treatment progress of metastatic cervical carcinoma with an unknown primary

Metastatic cervical carcinoma with an unknown primary (MCCUP) represents a heterogeneous group syndrome of cancers. The current data were analyzed, and the diagnosis and treatment progress of MCCUP were stated. Positron emission tomography computed/tomography(PET/CT) has a high value in the detection of primary tumors in patients with MCCUP. Panendoscopy and molecular testing, such as microRNA signatures and microsatellite analysis, also improve the diagnosis of MCCUP. Surgery and radiation therapy remain the main approaches of MCCUP treatment. Most doctors agree that surgery is the first choice for patients with N_1-2 disease. However, radiotherapy still plays an important role in the treatment of MCCUP. Today, salivarypreserving intensity-modulated radiation therapy has become the standard radiation technique for MCCUP.