Prognostic value of expression of EGFR and nm23 for locoregionally advanced nasopharyngeal carcinoma |
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Authors: | Xiu Juan Cao Jun Fang Hao Xin Hua Yang Peng Xie Lan Ping Liu Chun Ping Yao Jin Xu |
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Institution: | (1) Department of Radiation Oncology, Shandong Tumor Hospital and Institute, 250117 Jinan, China |
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Abstract: | The purpose of this study was to evaluate the prognostic value of expression of EGFR and nm23 in patients with advanced-stage
nasopharyngeal carcinoma (NPC). The study population comprised 127 patients with stage III–IVa NPC with sufficient pretreatment
tumor biopsy specimens from 2003 to 2004 and clinical follow-up data. The expression of EGFR and nm23 was detected by immunohistochemistry.
Survival analysis was performed using Kaplan–Meier method. The correlation between pretreatment expression of EGFR and nm23,
and the effectiveness of chemoradiotherapy was analyzed. The EGFR expression was correlated with primary lesion stage and
clinical stage (P = 0.001, 0.002, respectively). There was a statistically significant association between nm23 expression and local lymph
node stage (P = 0.000). The positive EGFR expression had a higher recurrent rate than the negative (P = 0.015). The positive nm23 expression had a lower distant metastasis rate than the negative (P = 0.021). Negative expression of EGFR had a significantly better 5-year OS and DFS than positive expression (P = 0.015, 0.013, respectively). Positive expression of nm23 had a significantly higher 5-year OS and DFS than negative expression
(P = 0.001, 0.006, respectively). Multivariate analysis indicated that both pretreatment EGFR and nm23 expression were strong
independent factors for the overall survival of patients with NPC (P = 0.000, 0.000, respectively). Our data suggested that EGFR and nm23 can serve as reliable biomarkers for prognosis prediction
in patients with NPC who may benefit from alternate treatment strategy and targeted treatment. |
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