| 三硝基甲苯的生殖毒性 |
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| 引用本文： | 杨荫森,张慧泉.三硝基甲苯的生殖毒性[J].中华劳动卫生职业病杂志,1992,10(3):144-145,149. |
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| 作者姓名： | 杨荫森 张慧泉 |
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| 作者单位： | 黑龙江省劳动卫生职业病研究所 哈尔滨150010
(杨荫森，张慧泉，慈杰元，杨维玲，张洪英，蒋博，卢刚)，黑龙江省劳动卫生职业病研究所 哈尔滨150010(张家儒) |
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| 摘 要： | NT使胎鼠体重增长缓慢、胎鼠骨骼发育迟缓、肋骨畸形率增高、行为发育(?)常、雌鼠受孕率降低。800mg/kg 组妊鼠骨髓、脐带血及胎鼠肝血PCE(?)核率增高。TNT 染毒小鼠精子活动率降低、精子畸形率增高、精子数减少、睾丸细胞染色体畸变率增高,而且睾丸和卵巢形态学在电镜和光镜下均有改变。TNT 染毒大鼠血清E_2、FSH、LH 及T 含量亦有改变。结果表明(?)NT 对实验动物是具有生殖毒性的化学物质。
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| 关 键 词： | 三硝基甲苯 生殖毒性 |
A Study on Reproductive Toxicity of Trinitrotoluene |
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| Yang Yin-sen.A Study on Reproductive Toxicity of Trinitrotoluene[J].Chinese Journal of Industrial Hygiene and Occupational Diseases,1992,10(3):144-145,149. |
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| Authors: | Yang Yin-sen |
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| Institution: | Yang Yin-sen |
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| Abstract: | Trinitrotoluene(TNT)retards the weight gain and skeleton development of ratfetus,increases their rib malformation,and causes certain behavior disturb-ances.Gestation rate of mature female rats was lowered.At 800mg/kg,TNTincreases the micronucleus rate of PCE in bone marrow and umblical cordblood of pregnant rats and liver blood of fetus(P<0.05).Under light and elec-tron microscope,morphological changes of both ovary and testis can be ob-served,with decrease,of sperm motility and sperm count,increase of spermmalformation and chromosome aberration of testis cells.It also causes obvi-ous changes in serum reproductive hormone(E_2,FSH,LH,T)levels.These re-sults showed that TNT is toxic to the reproductive system of experimental an-imals. |
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| Keywords: | TNT Rat fetus Malformation Chromosome aberration Reproductive hormone |
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