新生儿呼吸窘迫综合征的联合预防措施

目的评价产前应用激素(地塞米松)和产后早期预防性应用肺表面活性制剂(PS)的联合措施,回顾性分析在新生儿呼吸窘迫综合征(NRDS)中的疗效和安全性。方法将2003-01~2005-05上海市第六人民医院收治的120例早产儿,分成联合预防组55例,单独预防组65例。联合预防组:产前用地塞米松且产后30 min内预防性应用PS。单独预防组:产前仅用地塞米松或产后仅应用PS的早产儿。两组比较,观察指标:(1)NRDS发病率;(2)CPAP通气率或机械通气率;(3)并发症发生率;(4)死亡率。结果联合预防组与单独预防组有显著性差异(P<0.01)。结论联合预防组比单独预防组能明显改善肺透明膜病的转归,减少并发症,降低死亡率。

Combination Prevention Study of Respiratory Distress Syndrome of Newborn

Objective To assess the prevention of dexameth antepartum and the pulmonary surfactant(ps) post partum to prevent the respiratory distress syndrome of newborn(NRSD) and analyze the curative effect and safety.Methods The 120 premature infants from January 2003 to May 2005 were divided into combining group(55 cases) and control group(65 cases).In combining group the dexameth was given antepartum 30 min and ps was given preventively after partum.The control group was only given dexameth or ps post partum.The NRDS incidence,CPAP ventilating rate,complication and mortality were compared between two groups.Results There was significant difference between two group with P<0.01(combining group was better than control group).Conclusion The outcome of hyaline membrane disease had been improved better in combining group than in control group so that could decrease the complication and mortality.