| 2型糖尿病大鼠大脑皮质HO-1表达的变化 |
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| 引用本文： | 和亚强,龚理,马洪伟,钟美蓉,陈志宏. 2型糖尿病大鼠大脑皮质HO-1表达的变化[J]. 承德医学院学报, 2011, 28(1): 1-3 |
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| 作者姓名： | 和亚强 龚理 马洪伟 钟美蓉 陈志宏 |
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| 作者单位： | 承德医学院,河北承德,067000 |
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| 基金项目： | 河北省教育厅项目，河北省科技厅项目 |
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| 摘 要： | 目的:探讨2型糖尿病大鼠大脑皮质血红素加氧酶1(HO-1)表达的变化.方法:20只SD大鼠随机分为正常埘照组和糖尿病模型组,每组10只.正常对照组大鼠不做任何处理;糖尿病模型组大鼠采用链脲佐菌素连续腹腔注射建立2型糖尿病大鼠模型,一周后以血糖≥16.7mmol/L作为成模标准.HE染色观察大脑皮质神经细胞的变化,分别采...
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| 关 键 词： | 2型糖尿病 大脑皮质 血红素加氧酶1 |
CHANGES OF EXPRESSION OF HO-1 IN CORTEX OF TYPE 2 DIABETIC RATS |
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| HE Ya-qiang,GONG Li,MA Hong-wei,et al. CHANGES OF EXPRESSION OF HO-1 IN CORTEX OF TYPE 2 DIABETIC RATS[J]. Journal of Chengde Medical College, 2011, 28(1): 1-3 |
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| Authors: | HE Ya-qiang GONG Li MA Hong-wei et al |
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| Affiliation: | HE Ya-qiang,GONG Li,MA Hong-wei,et al(Chengde Medical College,Hebei Chengde 067000,China) |
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| Abstract: | Objective:To investigate the changes of hemeoxygenase-1(HO-1) expression in cerebral cortex of type 2 diabetic rats.Methods:20 male SD rats were randomly divided into normal control group and diabetes model group(n=10).The diabetes model rats were made by continuous intraperitoneal injection of streptozotocin and blood glucose≥16.7mmol/L was taken as the standard after 1 week.The morphological changes of neurocytes were observed by HE staining.Western Blotting was used to detect the expression of HO-1 protein and RT-PCR was used to detect the expression of HO-1 mRNA in cerebral cortex.Results:Degeneration of neurocytes and inspissation of karyon were observed in cerebral cortex of diabetic rats.The expression of HO-1 protein and mRNA in cerebral cortex of diabetic rats were obviously higher than normal control rats(P <0.01).Conclusions:The HO-1 expression in cerebral cortex of diabetic rats is obviously up regulated,this maybe one of the mechanisms of nervous system injury during diabetes mellitus. |
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| Keywords: | Type 2 diabetes mellitus Cerebral cortex HO-1 |
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