| 慢性肾小球疾病患者血和尿中t-PA和PAI-1的改变及其意义 |
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| 引用本文： | 沈蕾,张威,王兆钺.慢性肾小球疾病患者血和尿中t-PA和PAI-1的改变及其意义[J].血栓与止血学,2004,10(1):11-13. |
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| 作者姓名： | 沈蕾 张威 王兆钺 |
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| 作者单位： | 苏州大学附属第一医院,苏州,215006 |
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| 摘 要： | 目的:探讨慢性肾小球疾病患者血浆和尿液中t-PA和PAI-1含量的改变及其与疾病的关系。方法:用ELISA法分别检测慢性肾小球肾炎(CGN)、慢性肾功能不全(CRF)、肾病综合征(NS)及正常对照组的血浆和尿液t-PA和PM-1含量。结果:血浆t-PA在NS组明显升高(P<0.05),其他肾小球疾病组有一定升高。CRF组与NS组的尿t-PA较正常对照组明显下降(P<0.01)。尿PAI-1各组与对照组相比均有明显减低(P<0.05)。结论:尿液中t-PA和PAI-1含量较血液中浓度更能反映肾小球疾病状态。
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| 关 键 词： | 慢性肾小球疾病 t-PA PAI-1 血浆 尿液 肾功能 纤溶系统 |
| 文章编号： | 1009-6213(2004)01-0011-03 |
| 修稿时间： | 2003年5月20日 |
Alterations of Plasma and Uric t-PA and PAI-1 in Patients with Chronic Glomerular Diseases |
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| SHEN Lei,ZHANG Wei,WANG Zhao-yue
The First Affiliated Hospital of Suzhou University,Suzhou,China.Alterations of Plasma and Uric t-PA and PAI-1 in Patients with Chronic Glomerular Diseases[J].Chinese Journal of Thrombosis and Hemostasis,2004,10(1):11-13. |
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| Authors: | SHEN Lei ZHANG Wei WANG Zhao-yue
The First Affiliated Hospital of Suzhou University Suzhou China |
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| Institution: | SHEN Lei,ZHANG Wei,WANG Zhao-yue
The First Affiliated Hospital of Suzhou University,Suzhou,215006,China |
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| Abstract: | Objective:To measure the plasma and urine levels of t-PA and PAI-1 in chronic renal glomerular diseases and to study their clinical significance. Methods: ELBA method was used to detect the plasma and urine levels of t-PA and PAI-1. Results: the plasma levels of t-PA in renal disease groups were higher than that of the control group. A significant difference in t-PA levels was observed between nephritic syndrome and normal control group.The urine levels of PAI-1 were all lower than the normal control group(P < 0.05) .The urine levels of t-PA in CRF and NS groups were significant lower than in the control group( P < 0.01) . Conclusion: The levels of t-PA and PAI-1 in urine are more sensitive to reflect the condition of giomerular diseases than those in plasma. |
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| Keywords: | Glomerular disease t-PA PAL-1 |
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