MR spectroscopy study of dichloroacetate treatment after ischemic stroke |
| |
| Authors: | Graham G D Barker P B Brooks W M Morris D C Ahmed W Bryniarski E Hearshen D O Sanders J A Holshouser B A Turkel C C |
| |
| Affiliation: | University of New Mexico and the Albuquerque Veterans Administration Medical Center, 87108, USA. graham@unm.edu |
| |
| Abstract: | In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
