| 听神经瘤的微血管计数与血管内皮因子表达及其临床意义 |
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| 引用本文： | 孙彦辉,周建欣,王长坤. 听神经瘤的微血管计数与血管内皮因子表达及其临床意义[J]. 中国实验诊断学, 2002, 6(2): 88-89 |
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| 作者姓名： | 孙彦辉 周建欣 王长坤 |
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| 作者单位： | 1. 吉林大学第一医院,神经外科,吉林,长春,130021
2. 佳木斯中心医院 |
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| 摘 要： | 目的 通过检测听神经瘤的微血管计数（ＭＶＣ）与血管内皮因子（ＶＥＧＦ）表达，探讨二者之间的关系及其在临床上的意义。方法 采用免疫组织化学（Ｓ－Ｐ）方法，检测８７例听神经瘤组织中Ｍ ＶＣ与ＶＥＧＦ表达，结果进行ｘ２检验分析。结果ＭＶＣ、ＶＥＧＦ表达与肿瘤直径大小无相关性（Ｐ＞０．０５），与肿瘤生长速度呈明显正相关（Ｐ＜０．０１）；ＶＥＧＥＦ表达与ＭＶＣ之间呈明显正相关（Ｐ＜０．０１）。结论ＭＶＣ与ＶＥＧＦ表达能够反映听神经瘤的生长情况，并为制定肿瘤的治疗方案和判断预后提供重要的信息。
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| 关 键 词： | 听神经瘤 微血管计数 血管内皮因子 临床意义 颅内肿瘤 |
| 文章编号： | 1007-4287(2002)02-0088-02 |
| 修稿时间： | 2001-07-07 |
Clinical significance of microvessel count and VEGF expression in acoustic neuroma |
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| SUN Yan-hui,ZHOU Jian-xin,WANG Chang-kun.. Clinical significance of microvessel count and VEGF expression in acoustic neuroma[J]. Chinese Journal of Laboratory Diagnosis, 2002, 6(2): 88-89 |
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| Authors: | SUN Yan-hui ZHOU Jian-xin WANG Chang-kun. |
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| Abstract: | Objective To study Microvessel Count ( MVC) and VEGF expression in acoustic neuroma and their clinical significance. Methods The immunohistochemical(S - P) method was used to detect MVC and the expression of VEGF in 87 cases of acoustic neuroma. Results MVC and VEGF expression were not related to the tumor's size( P> 0.05) ,but were closely related to the tumor's growth rate ( P < 0.01), and MVC was associated with VEGF expression ( P < 0.01) .Conclusions MVC and the expression of VEGF can reflect the condition of acoustic neuroma growth and be helpful to determine the treatment plan and anticipate the prognosis of the tumor. |
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| Keywords: | acoustic neuroma microvessel count VEGF |
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