131I治疗对Graves眼病转归的影响

目的 分析131I治疗后Graves甲状腺功能亢进症(甲亢)疗效与Graves眼病转归的相关关系,探讨131I治疗对Graves眼病转归的影响.方法 652例Graves甲亢合并Graves眼病的患者,均按照常规程序一次性给予治疗量的131I.服用131I前测量患者眼球突出度,并详细记录眼部症状和特征.治疗结束后定期随...

Effect of 131I therapy on outcomes of Graves' ophthalmopathy

Objective To analyze the correlation between the therapeutic effect of Graves'hyperthyroidism and the outcomes of Graves' ophthalmopathy after 131I therapy,and to explore the effect of 131I treatment on turnout of Graves' ophthalmopathy.Methods Six hundreds and fifty-two patients of Graves' disease accompanied with Graves' ophthalmopathy,received one-time 131I treatment according to routine procedure.We recorded exophthalmometer readings,the signs and symptoms of eyes before therapy.Regular follow-up and appraisal of curative effect were carried out.Results At least six months after 131Itherapy,the effective rate of Graves' hyperthyroidism and Graves' ophthalmopathy were 94.3％ and 73.3％respectively.The total effective rate of hyperthyroidism with ophthalmophy was 71.2％.There was a significant correlation between the prognosis of Graves' ophthalmopathy and therapeutic efficacy of hyperthyroidism (r=0.302,P＜0.05).The outcomes of Graves' ophthalmopathy had no statistically differences between cured and hypothyroidism groups after 131I therapy (x2=0.296,P＞0.05).Conclusions The key to treat Graves' ophthalmopathy is the cure of Graves' hyperthyroidism through 131I therapy.The timely diagnosis and replacement treatment of hypothyroidism can effectively avoid the aggravation of Graves'ophthalmopathy after 131I therapy.