噬菌体展示肽库技术在肿瘤诊治研究中的应用

噬菌体展示肽库技术是将高度多样性的多肽与噬菌体衣壳蛋白融合表达,呈现于噬菌体表面的多肽具有相对独立的空间结构,能与配体结合,从而筛选特异性分子表位,其已成为肿瘤诊治研究的重要手段和有力工具.筛选与肿瘤细胞或血管表面细胞特异结合的多肽作为核素载体,制成探针,可以对肿瘤进行早期诊断和转移灶的定位,还可以进行核素治疗；以多肽...

Phage display peptide library technology's application in the diagnosis and therapy of tumor

Phage display peptide library technology facilitates displaying peptides of high diversity on the surface of phage coat proteins,which with their independent space structure bind with ligands to screen the specific molecule epitopes.With the development of this technology,it becomes an effective and powerful tool in tumor research.As nuclide carrier,peptides screened from phage display library binding specifically with tumor cells and tumor blood vessels,can be manufactured into a probe for prophase diagnosis of tumor,localization of metastasis and nuclide therapy.Targeting chemotherapy drugs on the basis of peptides greatly lower the risk of killing normal tissue and organs,which impulses entering a new therapy time.