小剂量hCG联合HMG对低促性腺激素性腺功能减退症不育患者卵巢刺激的疗效观察

目的：探讨小剂量人绒毛膜促性腺激素（hCG）联合人绝经期促性腺激素（HMG）应用于低促性腺激素性腺功能减退症（HH）患者的卵巢刺激的可行性及其疗效。方法：对5例HH患者采用50 IU hCG联合HMG进行卵巢刺激，应用阴道超声、测量血清性激素等方法监测卵泡生长发育。结果：4例患者进行了诱发排卵6个周期，平均排卵（2.6±1.5）个，诱发排卵成功率100%，累积妊娠率100%。无患者改行多余卵泡穿刺术或体外受精-胚胎移植术，未发生中、重度卵巢过度刺激综合征，未发生高序多胎妊娠；均分娩单胎健康婴儿。1例患者进行控制性超排卵1个周期，穿刺7个卵泡，获卵5个，受精3个，分裂形成2个优质胚胎，胚胎移植后妊娠，足月分娩1个健康新生儿。结论：小剂量hCG联合HMG能够安全、有效地应用于HH患者的卵巢刺激，改善卵巢刺激的结局。

Effect of Ovarian Stimulation with Low-Dose hCG Combined with HMG on Infertility Patients with Hypogonadotropic Hypogonadism

Objective：To investigate the effect of ovarian stimulation with low-dose hCG combined with HMG on infertility patients with hypogonadotropic hypogonadism. Mehtods：Five infertility patients with hypogonadotropic hypogonadism were undergone ovarian stimulation with 50 IU hCG combined with HMG. Vaginal ultrasound-B，serum sexual hormone were used to monitor determine follicular development. Results：Four infertility patients with hypogonadotropic hypogonadism were undergone ovulation induction with six cycles，the mean number of ovulation was 2.6±1.5，ovulation rate was 100%，cumulating pregnancy rate was 100%. No moderate and severe OHSS occurred. No patients were undergone with surplus follicle aspiration or switched to IVF-ET. No patients were with high order multiple pregnancies. One patient with hypogonadotropic hypogonadism was undergone controlled ovarian hyperstimulation（COH） for one cycle，7 follicles were undergone aspiration，5 oocytes were harvested. After insemination，3 zygotes formed，and cleaved into 2 good-quality embryos. With embryo-transfer， one embryo was found in uterine cavity，one in tube. After surgery，the patient delivered one infant finally. Conclusions：Low-dose hCG combined with HMG could be safely and effectively used to ovarian stimulation on infertility patients with hypogonadotropic hypogonadism，and could improve the results of ovarian stimulation.