| Th17细胞与哮喘的研究进展 |
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| 引用本文： | 胡岩岩,王亚亭. Th17细胞与哮喘的研究进展[J]. 国际儿科学杂志, 2011, 38(6): 579-582. DOI: 10.3760/cma.j.issn.1673-4408.2011.06.016 |
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| 作者姓名： | 胡岩岩 王亚亭 |
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| 作者单位： | 安徽医科大学第一附属医院儿科,合肥,230032 |
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| 摘 要： | 支气管哮喘是一种慢性炎症性气道疾病,以往认为辅助性T细胞1 (Th1) /Th2比例失衡是哮喘发病的重要机制.近年发现了一种以产生IL-17为主要细胞因子的Th17细胞,在哮喘的发病机制中具有重要作用,IL-17还具有对哮喘的负性调节作用,有可能成为治疗哮喘的有意义的靶目标.
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| 关 键 词： | 支气管哮喘 Th17细胞 IL-17 |
Progress of asthma and Th17 cells |
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| HU Yan-yan,WANG Ya-ting. Progress of asthma and Th17 cells[J]. International Journal of Pediatrics, 2011, 38(6): 579-582. DOI: 10.3760/cma.j.issn.1673-4408.2011.06.016 |
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| Authors: | HU Yan-yan WANG Ya-ting |
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| Abstract: | Bronchial asthma is a chronic inflammation airway disease.The imbalance of T helper cell (Th) 1/Th2 immunity plays an important role in the pathogenesis of allergic asthma.Recent years a new T cell lineage has been recognized as Thl7 cells because they can produce cytokines interleukin-17.The new studies find that interleukin-17 is a negative regulator of asthma,and interleukin-17 or Th17 cells may represent an interesting therapeutic target in asthma. |
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| Keywords: | Bronchial asthma Th17 cells Interleukin-17 |
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