Efficacy of micafungin in combination with other drugs in a murine model of disseminated trichosporonosis |
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Authors: | Serena Carolina Pastor F Javier Gilgado Félix Mayayo Emilio Guarro Josep |
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Affiliation: | Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili. Carrer Sant Lloren?, 21 43201 Reus, Spain. |
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Abstract: | Using a murine model of disseminated infection caused by Trichosporon asahii, we have evaluated the efficacies of amphotericin B (AMB; 1 mg/kg of body weight/day), fluconazole (FLC; 20 mg/kg/twice a day), and micafungin (MFG; 5 mg/kg/twice a day). We tested these drugs alone and in combination (MFG with AMB and MFG with FLC). MFG with AMB showed a synergistic effect and demonstrated a higher degree of efficacy in prolonging survival and reducing the kidney fungal burden than either agent alone. The combination MFG with FLC was able to reduce significantly the kidney fungal burden in comparison to that achieved with either drug administered alone. |
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