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| 丙二醇-氯化钠-水三元溶液相图及其在血小板低温保存中的应用 | |
| 引用本文： | 刘景汉,Dayong Gao,何立群,Lip Kean Moey,Kegang Hua,刘作斌.丙二醇-氯化钠-水三元溶液相图及其在血小板低温保存中的应用[J].中国实验血液学杂志,2003,11(1):92-95. |
| 作者姓名： | 刘景汉 Dayong Gao 何立群 Lip Kean Moey Kegang Hua 刘作斌 |
| 作者单位： | 1. 解放军总医院输血科,解放军临床输血中心,北京,100853 2. Department of Mechnical Engineering and Center for Biomedical Engineering,University of Kentucky,Lexington,Kentucky 40506,USA;中国科技大学热科学与能源工程系低温生物医学工程研究所,合肥,230027 3. 中国科技大学热科学与能源工程系低温生物医学工程研究所,合肥,230027 4. Department of Mechnical Engineering and Center for Biomedical Engineering,University of Kentucky,Lexington,Kentucky 40506,USA |
| 摘 要： | 为了获得血小板冰冻保护液（丙二醇/氯化钠/水，PG/NaCl/H2O）冰冻降温的数学模型，本研究使用差示扫描量热仪分别测定出不同浓度和不同比例条件下丙二醇/氯化钠/水三元溶液的凝固点（Tf），然后将已有的公式和实验所得的数据通过计算机进行拟合。结果获得了一个数学模型，该数学模型描述的是在PG/NaCl/H2O溶液中Tf变化与溶质浓度和PG/NaCl(质量比)两个参数变化之间的函数关系。结论：把该方程与血小板的渗透性特性的参数相结合，可以描述在平衡冷冻状态下，不同PG浓度时血小板的体积变化，指导血小板低温保存。 |
| 关 键 词： | 血小板低温保存 低温保存液 相图 熔点 丙二醇 |
The Phase Diagram for the Ternary System Propylene Glycol-Sodium Chloride-Water and Their Application to Platelet Cryopreservation |
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| Dayong Gao,Lip Kean Moey,Kegang Hua.The Phase Diagram for the Ternary System Propylene Glycol-Sodium Chloride-Water and Their Application to Platelet Cryopreservation[J].Journal of Experimental Hematology,2003,11(1):92-95. | |
| Authors: | Dayong Gao Lip Kean Moey Kegang Hua |
| Institution: | Department of Blood Transfusion, General Hospital of PLA, Centre for Clinic Blood Transfusion Medicine of PLA, Beijing, 100853, China. |
| Abstract: | In order to acquire freezing model of the cryopretective solution (NaCl propylene glycol water ternary system)for platelet, the melting points (T f) of this cryopretective solutions with different solute concentration and different ratio of PG mass to NaCl mass were measured by using a differential scanning calorimeter (DSC), and these experimental data were fitting by computer. An empirical equation was derived which characterized the Tf as a function of the solute concentration and the ratio of PG mass to NaCl mass inside this solution. It was concluded that the equilibrium freezing model for human platelets in this system could be used to instruct platelet cryopreserving techniques. |
| Keywords: | platelet cryopreservation cryoprotective solution phase diagram melting point propylene glycol |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |