Flare-up reactions and desensitization from oral dosing in chromate-sensitive guinea pigs |
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Authors: | Ole B. Christensen Monica B. Christensen Howard I. Maibach |
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Affiliation: | Department of Dermatology, University of Lund, General Hospital, Malmö, Sweden;Department of Dermatology, University of California San Francisco, San Francisco, California, USA |
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Abstract: | Flare-up reactions were induced in potassium dichromate hypersensitive guinea pigs by a single oral dose of 55 mg/kg. This dose is systemically toxic and higher than the dose required to induce the same reactions in humans. A total oral dose of potassium dichromate of 90-115 mg/kg induced immunological unresponsiveness for at least 6 weeks. With limitations, the guinea pig model may be helpful in screening the hyposensitization capacity of different haptens dosed orally. |
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Keywords: | Guinea pigs potassium dichromate ingestion flare-up reactions hyposensitization |
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