Modification of glybenclamide hypoglycaemia by verapamil in rabbits |
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| Authors: | K K Saxena S Lata R S Saxena A Kumar V K Srivastava |
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| Institution: | Department of Pharmacology, L.L.R.M. Medical College, Meerut. |
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| Abstract: | The study was designed to demonstrate the interaction between verapamil and glybenclamide on blood glucose in rabbits. Glybenclamide (0.05 mg/kg, po) induced hypoglycaemia was observed 1 h after treatment and persisted till 3 h. Verapamil (8 mg/kg, sc) per se produced hyperglycaemia which lasted for 2 1/2 hr. Concurrent administration of verapamil was found to impair significantly the hypoglycaemic response of glybenclamide. |
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