中山大学附属第一医院241例药品不良反应报告分析

目的 了解药品不良反应（ADR）发生的规律、特点及引发的相关因素,为临床用药安全与合理用药提供参考.方法 统计中山大学附属第一医院2011～2012年上报的241例ADR报告,按患者性别、年龄、给药途径、引起ADR的药品类型、ADR涉及器官或系统,以及ADR临床表现等进行回顾性分析.结果 241例ADR报告中涉及的药品共12大类,其中抗菌药物引发的ADR最多,其次是心脑血管类药物；静脉注射给药引发的ADR最多；ADR累计的器官及系统以皮肤及其附件损害最为常见,其次是中枢神经系统损害.结论 药品不良反应的发生与多种因素有关,临床应坚持不良反应的报告和监测,以减少或避免ADR的发生,促进临床合理用药,保证患者用药安全.

Analysis of 241 Cases of Adverse Drug Reaction Reports in Our Hospital

Objective To analyze the characteristics, regularity and clinical manifestation of adverse drug reactions in The first Affiliated Hospital, Sun Yat-Sen University, and to provide reference for rational use of drugs in the clinic. Methods A total of 241 ADR cases recorded in our hospital during 2011- 2012 were summarized and analyzed. Results Of the 241 ADR cases, the main categories of drugs that induced ADR were antibacterial drugs, and intravenous injection was the main route. The most common clinical manifestations were lesions of skin and its appendages, followed by damage in central nervous system. Conclusion Monitoring of ADR should be strengthened and the use of drugs should be standardized so as to reduce or avoid the occurrence of ADR.