| 注射用洛铂与氯化钠注射液配伍的稳定性研究 |
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| 引用本文： | 姜婧,杨水艳,任艳丽,余娟,晏彩先,刘伟平.注射用洛铂与氯化钠注射液配伍的稳定性研究[J].中国药事,2013(10):1088-1089,1099. |
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| 作者姓名： | 姜婧 杨水艳 任艳丽 余娟 晏彩先 刘伟平 |
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| 作者单位： | 昆明贵金属研究所,昆明650106 |
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| 基金项目： | 国家自然科学基金课题（编号201161010） |
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| 摘 要： | 目的 考察在不同温度（25℃、37℃）条件下,注射用洛铂与氯化钠注射液配伍的稳定性,为该药的临床合理应用提供理论依据.方法 将注射用洛铂溶解在氯化钠注射液中,放置在不同温度下,用高效液相色谱法检测不同温度下注射用洛铂与氯化钠注射液配伍24 h内的稳定性.结果 注射用洛铂与氯化钠注射液配伍后,在25℃和37℃条件下放置24 h内,含量无明显变化.结论 注射用洛铂可与氯化钠注射液配伍.
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| 关 键 词： | 注射用洛铂 氯化钠注射液 配伍稳定性 |
Stability of Combination Use of Lobaplatin for Injection and Sodium Chloride Injection |
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| Jiang Jing,Yang Shuiyan,Ren Yanli,Yu Juan,Yan Caixian and Liu Weiping.Stability of Combination Use of Lobaplatin for Injection and Sodium Chloride Injection[J].Chinese Pharmaceutical Affairs,2013(10):1088-1089,1099. |
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| Authors: | Jiang Jing Yang Shuiyan Ren Yanli Yu Juan Yan Caixian and Liu Weiping |
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| Institution: | (Kunming Institute of Precious Metals, Kunming 650106) |
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| Abstract: | Objective To investigate the stability of combination use of lobaplatin for injection and sodium chloride injection at different temperatures （25 ℃, 37 ℃） in order to provide theoretical basis for its clinical reasonable application. Methods Lobaplatin for injection was dissolved in sodium chloride injection, and the mixed solution was placed at different temperatures. HPLC was used to detect the changes in lobaplatin content in sodium chloride injection at 25 ℃ and 37 ℃ within 24 h. Results Lobaplatin for injection in sodium chloride injection at 25 ℃ and 37 ℃ for 24 h showed no significant changes. Conclusion Lobaplatin for injection can be used in combine with sodium chloride injection. |
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| Keywords: | lobaplatin for injection sodium chloride injection combination stability |
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