我院2011年度546例药品不良反应报告回顾性分析

目的 了解我院药品不良反应发生的特点及影响因素,为临床合理用药提供依据.方法 对我院2011年上报的546例ADR报告,分别从资料来源、患者性别、年龄、给药途径、所涉及药品种类、临床表现、结果等采用回归性分析.结果 546例ADR中,女性患者较多（占56.59％）；共涉及140种药品,其中抗感染药及中成药较多,分别占32.60％和20.51％;临床表现方面以皮肤及其附件反应最常见,其次是消化系统反应.结论 加强合理用药,特别是抗感染药及中药制剂的合理使用,减少ADR的发生.

Review and Analysis of 546 ADR Cases Reported in 2011 in Our Hospital

Objective To study the characteristics and influence factors of adverse drug reactions that occurred in our hospital, lay the basis for clinical rational drug use, and reduce the occurrence of ADR. Methods A total of 546 ADR cases of our hospital reported in 2011 were analyzed by regression analysis in terms of data source, patient gender, age, route of administration, drug types, clinical performance. Results Female patients predominated among the 546 ADR cases （accounting for 56.59%）. The ADR cases involved a total of 140 kinds of drugs the majority of which were antibiotic medicines and Chinese patent medicines, taking up 32.60% and 20.51% respectively; reactions of the skin and its appendages were the most common clinical manifestations, followed by the reactions of the digestive system. Conclusion Rational drug use, especially the use preparation, should be strengthened so as to reduce of anti-infectives and traditional Chinese medicine the occurrence of ADR