Synthesis and microbiological activity of some novel N-[2-(p-substitutedphenyl)-5-benzoxazolyl]-cyclohexyl carboxamide, -cyclohexyl acetamide and -cyclohexyl propionamide derivatives |
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Authors: | Arpaci Ozlem Temiz Sener Esin Aki Yalçin Ismail Altanlar Nurten |
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Affiliation: | Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Turkey. |
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Abstract: | The synthesis and microbiological activity of a new series of N-[2-(p-substitutedphenyl)-5-benzoxazolyl]-cyclohexyl carboxamide, -cyclohexyl acetamide and -cyclohexyl propionamide derivatives (4-11) is described. The in vitro microbiological activity of the compounds was determined against gram-positive, gram-negative bacteria and the yeast Candida albicans in comparison with standard drugs. Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity against the tested microorganisms. |
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Keywords: | 5-Amide-substituted benzoxazoles Antibacterial activity Antifungal activity |
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